Nano Area
Faculty
PhD: Hebrew University, Hadassah Medical School, 1991
BSc: Hebrew University, 1985
Nano Main Field: Iron acquisition constitutes a key challenge for pathogenic organisms. Fungal pathogens have evolved the ability to extract iron from host hemoglobin via a family of heme-binding cell surface proteins. These proteins form a network that transfers heme from one molecule to the next until it is internalized into the cell. We study the mechanics of this nano-relay network at the level of structure and interactions of the components (proteins) involved.
Research Interests:
1) Regulation and substrate specificity of phosphorylation-mediated ubiquitination;
2) Molecular mechanisms of heme-iron acquisition in the fungal pathogen Candida albicans;
3) Relation between cell cycle regulation and morphogenesis in C. albicans.