MD, University of Toronto 1977
Nano Main Field:
Our laboratory team is now focusing its attention on disease risk gene discovery and cellular mechanisms by discovering functional variants by combining homozygosity mapping, population wide association with whole exome capture and massively parallel sequencing followed by detailed cell biology and protein chemistry. Examples focus on kidney disease, phosphate balance disorders, cardiovascular health and disease and neurodegenerative disease.
In a second major set of projects - we have developed a novel platform using a human cellular microenvironment to study human tumorigenesis and anti-cancer therapy.
In the third major set of projects – we study and dynamics of DNA methylation in gene expression in health and inherited disease.
Human Molecular Genetics
Whole Exome Capture
Massively Parallel Sequencing Technologies
Disease Risk Gene Discovery
Cellular Machinery and Molecular Transporters