Akram Alian

Akram Alian



Nano Area:
Personal Home Page:

PhD: Faculty of Medicine, The Hebrew University of Jerusalem, Israel, 2002
MSc: Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Israel, 1997
BSc: Faculty of Agriculture, The Jordan University in Amman, Jordan, 1994

Nano Main Field:
X-Ray Crystallography of Host-Pathogen Interacting Molecules

Research Interests:
Scientists in the Alian lab seek to understand the molecular mechanisms of how viruses interact with the host cell and manipulate key cellular
processes to aid their replication. We study the structure and function of proteins and complexes involved in host-virus interactions using
interdisciplinary approaches, and at different scales and levels:

1.Structural biology: we use X-ray crystallography to decipher, at the atomic level, the molecular mechanisms of protein-protein and protein-nucleic
acid interactions, drug mode of action, and drug resistance .

2.Biochemistry: we use biochemical methodologies to study mechanisms of catalysis and substrate specificity of enzymes,
especially those involved in virus replication. We also focus on identifying and validating protein-protein interactions that are essential
in virus replication.

3.Virology: we use infection-incompetent viral vectors, cell based assays, and biochemical assays to study viral replication and interaction
with the host cell, as well as inhibition of viruses by peptides and small molecule drugs.